A surface chemistry approach to studying cell adhesion

被引：391

作者：

Mrksich, M ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2000年 / 29卷 / 04期

关键词：

D O I：

10.1039/a705397e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Model substrates that present peptide and carbohydrate ligands are becoming important mechanistic tools in cell biology. This review surveys the development of self-assembled monolayers of alkanethiolates on gold as a model substrate for studies of cell adhesion. The review begins with a background that illustrates the opportunity for using tailored substrates in biology and then addresses the characteristics that make monolayers well-suited for these studies. The review concludes with a discussion of recent work that is developing dynamic substrates wherein the activity of immobilized ligands can be modulated in real time.

引用

收藏

页码：267 / 273

页数：7

相关论文

共 38 条

[1]

AOTA S, 1994, J BIOL CHEM, V269, P24756

[2] Microelectrode arrays for stimulation of neural slice preparations [J].

Borkholder, DA ;

Bao, J ;

Maluf, NI ;

Perl, ER ;

Kovacs, GTA .

JOURNAL OF NEUROSCIENCE METHODS, 1997, 77 (01) :61-66

[3] Extracellular matrix signaling: integration of form and function in normal and malignant cells [J].

Boudreau, N ;

Bissell, MJ .

CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (05) :640-646

[4] Geometric control of cell life and death [J].

Chen, CS ;

Mrksich, M ;

Huang, S ;

Whitesides, GM ;

Ingber, DE .

SCIENCE, 1997, 276 (5317) :1425-1428

[5] Characterization and quantitation of NF-κB nuclear translocation induced by interleukin-1 and tumor necrosis factor-α -: Development and use of a high capacity fluorescence cytometric system [J].

Ding, GJF ;

Fischer, PA ;

Boltz, RC ;

Schmidt, JA ;

Colaianne, JJ ;

Gough, A ;

Rubin, RA ;

Miller, DK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (44) :28897-28905

[6] Covalent coupling of immunoglobulin G to self-assembled monolayers as a method for immobilizing the interfacial-recognition layer of a surface plasmon resonance immunosensor [J].

Disley, DM ;

Cullen, DC ;

You, HX ;

Lowe, CR .

BIOSENSORS & BIOELECTRONICS, 1998, 13 (11) :1213-1225

[7] SYNTHESIS, STRUCTURE, AND PROPERTIES OF MODEL ORGANIC-SURFACES [J].

DUBOIS, LH ;

NUZZO, RG .

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1992, 43 :437-463

[8] Adsorption of surfactants and proteins at fluid interfaces [J].

Fainerman, VB ;

Lucassen-Reynders, E ;

Miller, R .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1998, 143 (2-3) :141-165

[9] Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation [J].

García, AJ ;

Vega, MD ;

Boettiger, D .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (03) :785-798

[10] Design of self-assembled monolayers that release attached groups using applied electrical potentials [J].

Hodneland, CD ;

Mrksich, M .

LANGMUIR, 1997, 13 (23) :6001-6003

← 1 2 3 4 →