ACYCLIC STEREOCONTROL BASED ON CHELATION-CONTROLLED ENE REACTION WITH CHIRAL ALPHA-ALKOXYALDEHYDES AND BETA-ALKOXYALDEHYDES

被引：41

作者：

MIKAMI, K

LOH, TP

NAKAI, T

机构：

[1] Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(00)82265-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The Lewis acid-promoted ene reactions with chiral α- and β-benzyloxy aldehydes have been developed and shown to afford high levels of both diastereofacial (chelation) selection and simple diastereoselection (anti), thus providing an efficient method for stereocontrol over three contiguous chiral centers. © 1991.

引用

页码：13 / 16

页数：4

共 19 条

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[9] DIASTEREOCONTROL VIA LEWIS ACID-PROMOTED ENE REACTION WITH GLYOXYLATES AND ITS APPLICATION TO STEREOCONTROLLED SYNTHESIS OF A 22R-HYDROXY-23-CARBOXYLATE STEROID SIDE-CHAIN
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[J]. TETRAHEDRON LETTERS, 1988, 29 (48) : 6305 - 6308
[10] ASYMMETRIC GLYOXYLATE ENE REACTION CATALYZED BY CHIRAL TITANIUM COMPLEXES - A PRACTICAL ACCESS TO ALPHA-HYDROXY ESTERS IN HIGH ENANTIOMERIC PURITIES
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