FACTORS RELATED TO RENAL HEMODYNAMICS IN YOUNG TYPE-1 DIABETES-MELLITUS PATIENTS

被引：9

作者：

JOHANSSON, BL

BERG, U

FREYSCHUSS, U

HALL, K

TROELL, S

机构：

[1] Department of Clinical Physiology, Huddinge Hospital, Stockholm

[2] Department of Paediatrics, Huddinge Hospital, Stockholm

[3] Department of Endocrinology, Karolinska Hospital, Stockholm

[4] Department of Diagnostic Radiology, Huddinge Hospital, Stockholm

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 06期

关键词：

GLOMERULAR FILTRATION RATE; EFFECTIVE RENAL PLASMA FLOW; RENAL PARENCHYMAL VOLUME; INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II; NORADRENALINE;

D O I：

10.1007/BF00858628

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The influence of metabolic control (HbA1c), noradrenaline (NA) and insulin-like growth factors (IGF-I and insulin-dependent diabetes mellitus patients aged 11 - 17 years. Renal function was evaluated in terms of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). Renal size was determined as renal parenchymal volume (RPV) by ultrasonography. The parenchymal volume (RPV) by ultrasonography. The patients' HbA1c values ranged from 8.2% to 12.9% (normal range 5.5-8.5%) and their GFR and ERPF were higher than normal. Their IGF-II values were higher, and NA and IGF-I levels were lower than those of healthy controls. Inverse correlations between NA and GFR (r = -0.66) and NA and ERPF (r = 0.63) were found. No correlation was found between serum IGF-I and renal functional parameters. The IGF-II values correlated with GFR and HbA1c (r = 0.63, r = 0.70 respectively). There were linear correlations between RPV and GFR, RPV and ERPF, HbA1c and GFR, and ERPF and RPV. Decreased NA concentrations and increased IGF-II values appear to be factors contributing to renal hyperfunction in these patients.

引用

页码：589 / 592

页数：4

共 30 条

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