NEUROCHEMICAL AND HISTOCHEMICAL-STUDIES OF THE EFFECT OF A LESION OF THE NUCLEUS CUNEIFORMIS ON THE CHOLINERGIC INNERVATION OF DISCRETE AREAS OF THE RAT-BRAIN

被引：95

作者：

HOOVER, DB ^{[1
]}

JACOBOWITZ, DM ^{[1
]}

机构：

[1] NINCDS,CLIN SCI LAB,BLDG 10,RM 2D46,BETHESDA,MD 20014

来源：

BRAIN RESEARCH | 1979年 / 170卷 / 01期

关键词：

D O I：

10.1016/0006-8993(79)90944-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The innervation sites of the dorsal tegmental acetylcholinesterase (AChE)-containing pathway were examined in rats by combining histochemical and biochemical techniques. A lesion was placed in the nucleus cuneiformis (midbrain reticular formation) and brains were examined after 4 days survival for changes in AChE staining and choline acetyltransferase (ChAT) activity in discrete brain areas. An ipsilateral projection appears to exist to the anterior thalamic nuclei, lateral portion of the medial thalamic nucleus, parafascicular nucleus, pretectal nucleus, posterior thalamic nucleus, and deep layers of the superior colliculus. A possible bilateral innervation to the reticular nucleus of the thalamus and the dorsal and ventral lateral geniculates was found. The parallel use of AChE histochemistry and measurements of ChAT activity in discrete nuclei will be useful for future evaluation of cholinergic pathways. © 1979.

引用

页码：113 / 122

页数：10

共 23 条

[1] MINI-REVIEW - NATURE AND MECHANISMS OF CHOLINERGIC-MONOAMINERGIC INTERACTIONS IN BRAIN [J].