VITAMIN-E PROTECTS NERVE-CELLS FROM AMYLOID BETA-PROTEIN TOXICITY

被引：550

作者：

BEHL, C ^{[1
]}

DAVIS, J ^{[1
]}

COLE, GM ^{[1
]}

SCHUBERT, D ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROBIOL,LA JOLLA,CA 92093

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90837-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amyloid βprotein (ABP) is a 40 to 42 amino acid peptide which accumulates in Alzheimer's disease plaques. It has been demonstrated that this peptide and a fragment derived from it are cytotoxic for cultured cortical nerve cells. It is shown here that ABP and an internal fragment encompassing residues 25 to 35(β25-35) are cytotoxic to a clone of PC12 cells at concentrations above 1×10-9M and to several other cell lines at higher concentrations. Between 10-9 and 10-11 Mβ25-35 protects PC12 cells from glutamate toxicity. The antioxidant and free radical scavenger vitamin E inhibits ABP induced cell death. These results have implications regarding the prevention and treatment of Alzheimer's disease. © 1992.

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页码：944 / 950

页数：7

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