IGM M-PROTEIN IN A PATIENT WITH SENSORY-DOMINANT NEUROPATHY BINDS PREFERENTIALLY TO POLYSIALOGANGLIOSIDES

被引：51

作者：

OBI, T ^{[1
]}

KUSUNOKI, S ^{[1
]}

TAKATSU, M ^{[1
]}

MIZOGUCHI, K ^{[1
]}

NISHIMURA, Y ^{[1
]}

机构：

[1] UNIV TOKYO,INST BRAIN RES,TOKYO 113,JAPAN

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 86卷 / 02期

关键词：

SENSORY-DOMINANT NEUROPATHY; IGM M-PROTEIN; ANTIGANGLIOSIDE ANTIBODY; POLYSIALOGANGLIOSIDES;

D O I：

10.1111/j.1600-0404.1992.tb05069.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 77-year-old man presented sensory-dominant neuropathy associated with IgM M-protein reacting with various gangliosides. The M-protein bound to gangliosides with polysialosyl residue, such as GD1b, GD3, GT1b, GT3, GQ1b, and GQ1c. In addition, GD1a, GM3 and LM1, having a terminal monosialosyl epitope, were also recognized. Previously, Ilyas et al. described a similar case in which sensory symptoms were associated with IgM M-protein reacting with gangliosides containing a disialosyl group, such as GD3, GD1b, and GT1b, but not GM3 and GD1a. It is suggested that the reactivity of IgM M-protein with polysialogangliosides may be associated with the pathogenesis of sensory-dominant neuropathy.

引用

页码：215 / 218

页数：4

共 15 条

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