DESIGN, SYNTHESIS AND POTENTIAL USE OF 3,9-SUBSTITUTED XANTHENE HANDLES FOR SOLID-PHASE PEPTIDE-SYNTHESIS

被引：5

作者：

SOMLAI, C

NYERGES, L

PENKE, B

HEGYES, P

VOELTER, W

机构：

[1] ATTILA JOZSEF UNIV,DEPT ORGAN CHEM,H-6701 SZEGED,HUNGARY

[2] UNIV TUBINGEN,INST PHYSIOL CHEM,PHYS BIOCHEM ABT,W-7400 TUBINGEN 1,GERMANY

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1994年 / 336卷 / 05期

关键词：

D O I：

10.1002/prac.19943360509

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Theoretical calculations on different xanthene derivatives and related structures were performed and as a result conclusions could be drawn for the acid-lability of substituted xanthenes. (9-Hydroxyxanthene-3-oxy)acetic- and valeric acid (6a and 6b) were selected, synthesized in a six-step route, and 6b was tested for its applicabiliy as a handle for solid phase synthesis of peptides.

引用

页码：429 / 433

页数：5

共 25 条

[1] PREPARATION AND APPLICATION OF THE 5-(4-(9-FLUORENYLMETHYLOXYCARBONYL)AMINOMETHYL-3,5-DIMETHOXYPHENOXY)VALERIC ACID (PAL) HANDLE FOR THE SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE AMIDES UNDER MILD CONDITIONS [J].