SEQUENCE OF THE WT1 UPSTREAM REGION INCLUDING THE WIT-1 GENE

被引：23

作者：

GESSLER, M ^{[1
]}

BRUNS, GAP ^{[1
]}

机构：

[1] CHILDRENS HOSP MED CTR,DIV GENET,BOSTON,MA 02115

来源：

GENOMICS | 1993年 / 17卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1355

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Wilms tumor gene WT1 encodes a Cys2His2-type zinc finger protein that can bind DNA and function as a transcriptional regulator. The pathological spectrum of tumorigenesis and various developmental defects produced by different WT1 alterations suggests that WT1 controls a number of subsequent effector genes. To define the role of WT1 in these developmental processes it will be important to elucidate mechanisms that govern expression of WT1 itself. To facilitate mapping of the WT1 promoter region and 5' control elements we have determined the sequence upstream of the WT1 transcription unit. This includes the Wit-1 gene that is transcribed in the opposite direction. © 1993 Academic Press. All rights reserved.

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页码：499 / 501

页数：3

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