LTP IN THE DENTATE GYRUS IS ASSOCIATED WITH A PERSISTENT NMDA RECEPTOR-DEPENDENT ENHANCEMENT OF SYNAPTOSOMAL GLUTAMATE RELEASE

被引：42

作者：

CANEVARI, L

RICHTER-LEVIN, G

BLISS, TVP

机构：

[1] Division of Neurophysiology and Neuropharmacology, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, Mill Hill

来源：

BRAIN RESEARCH | 1994年 / 667卷 / 01期

关键词：

LONG-TERM POTENTIATION; MK-801; 4-AMINOPYRIDINE; POTASSIUM; VERATRIDINE;

D O I：

10.1016/0006-8993(94)91720-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LTP was induced unilaterally in the dentate gyrus of the anaesthetized rat by tetanic stimulation of the perforant path. Two hours after tetanization synaptosomes were prepared from control and potentiated sides, and the depolarization-induced release of endogenous amino acid neurotransmitters was compared in the two groups,using 4-aminopyridine, potassium or veratridine as depolarizing agents. Glutamate release was greater in synaptosomes from potentiated than control tissue with all three depolarizing agents, but the highest release from control synaptosomes and the most significant enhancement of release from ; potentiated synaptosomes was seen with veratridine. The tetanus-induced enhancement of veratridine-induced glutamate release was prevented by pretreatment with MK-801. The results indicate that the induction of LTP in the dentate gyrus is accompanied by a persistent enhancement in the ability of synaptosomes to release glutamate in response to a depolarizing stimulus.

引用

页码：115 / 117

页数：3

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