CHROMOSOME-ABNORMALITIES AND P53 EXPRESSION IN A SMALL-CELL CARCINOMA OF THE BLADDER

被引：14

作者：

ATKIN, NB ^{[1
]}

BAKER, MC ^{[1
]}

WILSON, GD ^{[1
]}

机构：

[1] MT VERNON HOSP,CRC GRAY LAB,NORTHWOOD,MIDDX,ENGLAND

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 79卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)00114-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome studies on a highly malignant tumor, a small cell carcinoma of the bladder (the first to be studied cytogenetically), showed a hypertriploid mainline and a hypertetraploid minor line. Extensive chromosomal rearrangements were present in both lines, some rearranged chromosomes being seen in only one of the lines, while others, derived from chromosomes 6, 9, 11, 13, and 18, were seen in both. Although different giant chromosomes were present in the two lines, they shared a possibly significant common feature: multiple copies of 2q. DNA flow cytometry confirmed that the tumor had a hypertriploid main mode and showed that dysplastic surface epithelium present in the histologic material also had a hypertriploid DNA index. p53 expression in the tumor was demonstrated by flow cytometry.

引用

页码：111 / 114

页数：4

共 10 条

[1] NONRANDOM CHROMOSOME CHANGES IN CARCINOMA OF THE CERVIX UTERI .1. 9 NEAR-DIPLOID TUMORS [J].