SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-DESAMINO AND 4-DEOXY ANALOGS OF 5,10-DIDEAZATETRAHYDROFOLIC ACID (DDATHF)

被引：8

作者：

SHIH, C

HU, Y

GOSSETT, LS

HABECK, LL

MENDELSOHN, LG

GRINDEY, GB

机构：

[1] Lilly Research Laboratories, ELi Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80736-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Either the 2-amino or the 4-oxo group of the potent GAR formyltransferase inhibitor 5,10-dideazatetrahydrofolic acid (DDATHF) was replaced with a hydrogen atom and their biological activity evaluated.

引用

页码：2657 / 2660

页数：4

共 12 条

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