EFFECT OF ANGIOTENSIN-II BLOCKADE ON DIETARY PROTEIN-INDUCED RENAL GROWTH

被引：7

作者：

SMITH, LJ ^{[1
]}

ROSENBERG, ME ^{[1
]}

HOSTETTER, TH ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT MED,DIV RENAL DIS & HYPERTENS,UMHC BOX 736,420 DELAWARE ST SE,MINNEAPOLIS,MN 55455

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1993年 / 22卷 / 01期

关键词：

RENIN; ANGIOTENSIN; DIETARY PROTEIN; RENAL GROWTH;

D O I：

10.1016/S0272-6386(12)70177-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Dietary protein provokes renal growth and synthesis of renin. Because angiotensin II (AII) has growth-promoting properties, we tested the possibility that protein-induced renal growth depends on angiotensin II. Normal adult male rats placed on a high-protein diet (50%) developed significant renal and glomerular growth over 6 days compared with rats on a low-protein diet (6%). However, neither angiotensin converting enzyme inhibition with enalapril nor angiotensin receptor antagonism with losartan influenced the degree of whole-kidney, cortical tubular, or glomerular growth. Thus, angiotensin II is not a necessary factor in dietary protein-induced renal growth in normal adult rats. © 1993, National Kidney Foundation. All rights reserved. All rights reserved.

引用

页码：120 / 127

页数：8

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