EFFECT OF MYCOPHENOLIC-ACID ON EPSTEIN-BARR-VIRUS INFECTION OF HUMAN B-LYMPHOCYTES

被引：32

作者：

ALFIERI, C

ALLISON, AC

KIEFF, E

机构：

[1] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA

[3] SYNTEX INC, PALO ALTO, CA 94303 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 01期

关键词：

D O I：

10.1128/AAC.38.1.126

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effect of mycophenolic acid (MPA) on the growth of Epstein-Barr virus (EBV)-transformed B cells and on EBV lytic-cycle gene expression was investigated. MPA inhibited the proliferation of newly infected or established EBV-transformed B-cell lines but was not able to block cell growth transformation or the viral lytic cycle. These results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders.

引用

页码：126 / 129

页数：4

共 27 条

[1] EARLY EVENTS IN EPSTEIN-BARR-VIRUS INFECTION OF HUMAN LYMPHOCYTES-B
ALFIERI, C
BIRKENBACH, M
KIEFF, E
[J]. VIROLOGY, 1991, 181 (02) : 595 - 608
[2] Allison A C, 1977, Ciba Found Symp, P207
[3] ALLISON AC, 1991, TRANSPL P, V23, P10
[4] BURNETTE WN, 1981, ANAL BIOCHEM, V112, P195, DOI 10.1016/0003-2697(81)90281-5
[5] CLEARY ML, 1986, EPSTEINBARR VIRUS RE, P163
[6] COHEN MB, 1983, CANCER RES, V43, P1587
[7] LYMPHOCYTE-SELECTIVE ANTIPROLIFERATIVE AND IMMUNOSUPPRESSIVE EFFECTS OF MYCOPHENOLIC-ACID IN MICE
EUGUI, EM
MIRKOVICH, A
ALLISON, AC
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1991, 33 (02) : 175 - 183
[8] LYMPHOCYTE-SELECTIVE CYTOSTATIC AND IMMUNOSUPPRESSIVE EFFECTS OF MYCOPHENOLIC-ACID INVITRO - ROLE OF DEOXYGUANOSINE NUCLEOTIDE DEPLETION
EUGUI, EM
ALMQUIST, SJ
MULLER, CD
ALLISON, AC
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1991, 33 (02) : 161 - 173
[9] FREISE CE, 1993, TRANSPLANT P, V25, P1758
[10] EPSTEIN-BARR VIRUS (EBV) INDUCED POLYCLONAL AND MONOCLONAL B-CELL LYMPHOPROLIFERATIVE DISEASES OCCURRING AFTER RENAL-TRANSPLANTATION - CLINICAL, PATHOLOGIC, AND VIROLOGIC FINDINGS AND IMPLICATIONS FOR THERAPY
HANTO, DW
GAJLPECZALSKA, KJ
FRIZZERA, G
ARTHUR, DC
BALFOUR, HH
MCCLAIN, K
SIMMONS, RL
NAJARIAN, JS
[J]. ANNALS OF SURGERY, 1983, 198 (03) : 356 - 369

← 1 2 3 →