FOS IMMUNOREACTIVITY ASSESSMENT ON HUMAN NORMAL AND PATHOLOGICAL BRONCHIAL BIOPSIES

被引：24

作者：

DEMOLY, P

CHANEZ, P

PUJOL, JL

GAUTHIERROUVIERE, C

MICHEL, FB

GODARD, P

BOUSQUET, J

机构：

[1] CHU MONTPELLIER,HOP ARNAUD VILLENEUVE,INSERM,CJF 9210,MALAD RESP CLIN,F-34059 MONTPELLIER 1,FRANCE

[2] CNRS,CRBM,INSERM,F-34059 MONTPELLIER,FRANCE

来源：

RESPIRATORY MEDICINE | 1995年 / 89卷 / 05期

关键词：

D O I：

10.1016/0954-6111(95)90003-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The transcription factor Fos is involved in cell proliferation and differentiation. Its expression in normal and pathological adult human tissues and cells has rarely been studied. We therefore studied bronchial biopsies obtained from 14 normal subjects (NS), 18 non-steroid-treated asthmatics, 10 corticosteroid-treated asthmatics and 10 patients with chronic bronchitis (CB), in addition to 34 patients with lung cancer (LC), by immunofluorescence for Fos immunoreactivity, using a highly specific polyclonal antibody. Bronchial tissue of 0/10 NS, 11/18 non-steroid-treated asthmatics, 1/10 steroid-treated asthmatics, 0/10 CB and 1/34 LC expressed Fos. In asthmatic patients, the expression was heterogeneous, localized to epithelial cells and correlated with the epithelium shedding (tau=0.45, P=0.0001). Corticosteroid-treated patients rarely expressed Fos, suggesting a role for this proto-oncogene in asthmatic bronchial inflammation. Fos was rarely expressed in the normal and pathological (CB, LC) proliferative compartment of the human bronchi, suggesting its low role in cell proliferation of the large airways.

引用

页码：329 / 335

页数：7

共 27 条

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