GCS1, A GENE ENCODING GAMMA-GLUTAMYLCYSTEINE SYNTHETASE IN THE FISSION YEAST SCHIZOSACCHAROMYCES-POMBE

被引：14

作者：

COBLENZ, A ^{[1
]}

WOLF, K ^{[1
]}

机构：

[1] RHEIN WESTFAL TH AACHEN,INST BIOL MIKROBIOL 4,D-52056 AACHEN,GERMANY

来源：

YEAST | 1995年 / 11卷 / 12期

关键词：

GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; GLUTATHIONE; SCHIZOSACCHAROMYCES POMBE;

D O I：

10.1002/yea.320111207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By complementation of a mutant resistant to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) we have identified the gcs1 gene, encoding a putative gamma-glutamylcysteine synthetase. The gene is possibly interrupted by two introns and has 49% identical and 80% similar amino acids compared with the homologous protein from rat. In comparison with the Saccharomyces cerevisiae homologue it possesses 41% identical and 74% similar amino acids. The gcs1 sequence appears in the EMBL database under Accession Number X 85017.

引用

页码：1171 / 1177

页数：7

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