MYOCARDIAL PLATELET TRAPPING AFTER CORONARY LIGATION IN PRIMATES (PAPIO-ANUBIS) - PLATELET TRAPPING IN INFARCT MARGINAL ZONE

51Cr-Labeled platelets were injected into baboons prior to coronary ligation. Area of ischemia and infarction was determined with an epicardial ECG grid. ST elevation of more than 4 mV was considered as the center of the region of ischemia. Platelets were found to accumulate in significantly higher concentrations at the margins of the infarct in the three animals sacrificed 6 hr after permanent ligation and in the center of the infarct in animals reperfused 3 hr after ligation and 3 hr prior to sacrifice. The data are interpreted as demonstrating platelet trapping in the margins of an evolving infarct which may play a role in infarct evolution. High concentration in the center of infarct in reperfused animals is consistent with the nonreflow phenomenon into the infarcted area. © 1979.