CARCINOGENICITY STUDY OF THE PESTICIDE DIELDRIN IN HAMSTERS

被引：18

作者：

CABRAL, JRP ^{[1
]}

HALL, RK ^{[1
]}

BRONCZYK, SA ^{[1
]}

SHUBIK, P ^{[1
]}

机构：

[1] UNIV NEBRASKA, MED CTR, EPPLEY INST RES CANC, OMAHA, NE 68105 USA

来源：

CANCER LETTERS | 1979年 / 6卷 / 4-5期

关键词：

D O I：

10.1016/S0304-3835(79)80040-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Syrian golden hamsters were fed for their lifespan a diet containing 0, 20, 60 and 180 ppm dieldrin. Tumor-bearing animals totaled 13% among control females and ranged between 3-15% in treated females. Of male controls, 8% had tumors and 16-23% of treated males had tumors. Incidences of endocrine organ tumors were comparable in all groups. A hepatoma was found in 1 female and 1 male fed 180 ppm dieldrin. Hamsters apparently tolerate higher doses of dieldrin than do mice and rats. No significant tumor incidence was observed in treated vs. control Syrian golden hamsters.

引用

页码：241 / 246

页数：6

共 20 条

[1]

AGTHE C, 1970, P SOC EXP BIOL MED, V134, P113, DOI 10.3181/00379727-134-34740

[2]

CABRAL JRP, 1977, FED PROC, V36, P1086

[3]

CABRAL JRP, 1979, 18TH ANN M SOC TOX

[4] TUMORIGENIC POTENTIAL OF ALDRIN AND DIELDRIN FOR MICE [J].

DAVIS, KJ ;

FITZHUGH, OG .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1962, 4 (02) :187-&

[5]

DEICHMANN WB, 1970, IND MED SURG, V39, P426

[6]

FITZHUGH O G, 1964, Food Cosmet Toxicol, V2, P551, DOI 10.1016/S0015-6264(64)80354-0

[7]

HAYES W J Jr, 1959, Bull World Health Organ, V20, P891

[8] DIELDRIN POISONING IN MAN [J].

HAYES, WJ .

PUBLIC HEALTH REPORTS, 1957, 72 (12) :1087-1091

[9] COMPARATIVE METABOLISM OF DIELDRIN IN RAT (CFE) AND IN 2 STRAINS OF MOUSE (CF1 AND LACG) [J].

HUTSON, DH .

FOOD AND COSMETICS TOXICOLOGY, 1976, 14 (06) :577-&

[10]

Jager KW., 1970, ALDRIN DIELDRIN ENDR

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