5-HT3 RECEPTOR ANTAGONISTS ATTENUATE COCAINE-INDUCED LOCOMOTION IN MICE

被引：96

作者：

REITH, MEA

机构：

[1] Center for Neurochemistry, N.S. Kline Institute for Psychiatric Research, New York, NY 10035, Ward's Island

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期

关键词：

(Mouse); 5-HT[!sub]3[!/sub] receptor antagonists; Cocaine; Locomotion;

D O I：

10.1016/0014-2999(90)90454-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 5-HT3 receptor antagonists ICS 205-930 and zacopride attenuated cocaine-induced locomotor activity in C57BL/6ByJ mice. In contrast, the aselective 5-HT1 and 5-HT2 receptor antagonist, methysergide did not affect the response to cocaine. The effect of the 5-HT3 receptor antagonists was not due to general sedation, because zacopride did not alter the locomotor response to caffeine. © 1990.

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页码：327 / 330

页数：4

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