GLYCOSYL-INOSITOL DERIVATIVES .3. SYNTHESIS OF HEXOSAMINE-INOSITOL-PHOSPHATES RELATED TO PUTATIVE INSULIN MEDIATORS

被引：29

作者：

BERLIN, WK ^{[1
]}

ZHANG, WS ^{[1
]}

SHEN, TY ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

TETRAHEDRON | 1991年 / 47卷 / 01期

关键词：

D O I：

10.1016/0040-4020(91)80003-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The disaccharides related to glycosyl phosphatidyl Inosltol anchors of membrane proteins, 4-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-myo-inositol-1-phosphate and 4-O-(2amino-2-deoxy-α-D-galactopyranosyl)-D-chiro-inositol-1-phosphate, have been prepared from optically resolved myo-inosltol derivatives. The chiro-inositol moiety was obtained by epimerlzatlon of a selectively blocked myo-inositol-trifiate ester. The resolved inositols were subsequently phosphoryiated to yield the disaccharide aglycones. The amino-sugar components were prepared by azidonitratlon of suitably protected glucal and galactal derivatives. The derived pyranosyl chlorides were then condensed with the inositol phosphates using silver triflate as the promoter. © 1991.

引用

页码：1 / 20

页数：20

共 21 条

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