PRODUCTION OF INTERLEUKIN-4 AND OTHER CYTOKINES FOLLOWING STIMULATION OF MAST-CELL LINES AND INVIVO MAST-CELLS BASOPHILS

被引：88

作者：

SEDER, RA

PAUL, WE

BENSASSON, SZ

LEGROS, GS

KAGEYSOBOTKA, A

FINKELMAN, FD

PIERCE, JH

PLAUT, M

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,JOHNS HOPKINS ASTHMA & ALLERGY CTR,DEPT MED,BALTIMORE,MD 21224

[2] NIAID,IMMUNOL LAB,BETHESDA,MD 20892

[3] HEBREW UNIV JERUSALEM,HADASSAH MED CTR,LAUTENBERG CTR TUMOR IMMUNOL,JERUSALEM,ISRAEL

[4] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814

[5] NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 94卷 / 1-4期

关键词：

D O I：

10.1159/000235345

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-3 (IL-3)-dependent mast cell lines, upon stimulation by calcium ionophores or by Fc-epsilon-RI cross-linking, express mRNA for, and secrete, a distinct pattern of cytokines, similar to those secreted by cloned mouse T cells of the T(H2) type. The mast-cell-derived cytokines include IL-3, IL-4 IL-5, and IL-6. Not only in vitro mast cell lines, but also in vivo derived peritoneal mast cells secrete cytokines. An in vivo derived cell, in mouse spleen and bone marrow, secretes IL-4 and other cytokines upon stimulation with calcium ionophores or by Fc-epsilon-RI cross-linking or Fc-gamma-RII cross-linking. The IL-4-producing cells are highly enriched in the Fc-epsilon-R+ subset of spleen and bone marrow cells. These Fc-epsilon-R+ cells produce large amounts of IL-4, and they have characteristics similar to those of immature mast cells and/or basophils. It is possible that cytokines produced by mast cells and/or basophils participate in allergic inflammatory diseases.

引用

页码：137 / 140

页数：4

共 17 条

[1] CROSS-LINKING FC-RECEPTORS STIMULATE SPLENIC NON-B, NON-T CELLS TO SECRETE INTERLEUKIN-4 AND OTHER LYMPHOKINES [J].