MECHANISMS OF THE PATHOGENIC AUTOIMMUNE-RESPONSE IN LUPUS - PROSPECTS FOR SPECIFIC IMMUNOTHERAPY

被引：8

作者：

DATTA, SK ^{[1
]}

MOHAN, C ^{[1
]}

DESAIMEHTA, A ^{[1
]}

机构：

[1] NORTHWESTERN UNIV, SCH MED, DEPT MICROBIOL IMMUNOL, CHICAGO, IL 60611 USA

来源：

IMMUNOLOGIC RESEARCH | 1995年 / 14卷 / 02期

关键词：

SYSTEMIC LUPUS ERYTHEMATOSUS; ANTI-DNA AUTOANTIBODIES; AUTOIMMUNE T CELL RECEPTORS; CD40; CD40-LIGAND; IMMUNOTHERAPY;

D O I：

10.1007/BF02918173

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A major step towards understanding the basic mechanism of systemic lupus erythematosus (SLE), the prototypic autoimmune disease that develops spontaneously, has been the identification of nucleosomes as a primary immunogen in this disease. The production of pathogenic autoantibodies in SLE results from an MHC class-II-restricted, cognate interaction between select populations of T helper cells and B cells that are specific for nucleosomal components. These observations pave the way for specific immunotherapy that blocks this pathogenic T and B cell interaction.

引用

页码：132 / 147

页数：16

共 156 条

[1] T-CELL RECEPTOR V-BETA GENES EXPRESSED BY IGG ANTI-DNA AUTOANTIBODY-INDUCING T-CELLS IN LUPUS NEPHRITIS - FORBIDDEN RECEPTORS AND DOUBLE-NEGATIVE T-CELLS [J].

ADAMS, S ;

ZORDAN, T ;

SAINIS, K ;

DATTA, SK .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (07) :1435-1443

[2] JUNCTIONAL REGION SEQUENCES OF T-CELL RECEPTOR BETA-CHAIN GENES EXPRESSED BY PATHOGENIC ANTI-DNA AUTOANTIBODY-INDUCING HELPER T-CELLS FROM LUPUS MICE - POSSIBLE SELECTION BY CATIONIC AUTOANTIGENS [J].

ADAMS, S ;

LEBLANC, P ;

DATTA, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11271-11275

[3]

ANDO DG, 1987, J IMMUNOL, V138, P3185

[4] LACK OF RELATIONSHIP BETWEEN SERUM GP70 LEVELS AND THE SEVERITY OF SYSTEMIC LUPUS-ERYTHEMATOSUS IN MRL/1 MICE [J].

ANDREWS, J ;

HANG, L ;

THEOFILOPOULOS, AN ;

DIXON, FJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (02) :458-462

[5] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[6]

ATANASSOV C, 1991, CLIN EXP IMMUNOL, V86, P124

[7]

ATKINSON MJ, 1985, J IMMUNOL, V135, P2524

[8] THE CD40 ANTIGEN AND ITS LIGAND [J].

BANCHEREAU, J ;

BAZAN, F ;

BLANCHARD, D ;

BRIERE, F ;

GALIZZI, JP ;

VANKOOTEN, C ;

LIU, YJ ;

ROUSSET, F ;

SAELAND, S .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :881-922

[9]

BERNSTEIN KA, 1995, J IMMUNOL, V154, P2424

[10] CELLULAR ONCOGENES AND RETROVIRUSES [J].

BISHOP, JM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :301-354

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