DEOXYRIBONUCLEIC-ACID FLOW CYTOMETRIC STUDY IN PHEOCHROMOCYTOMAS AND ITS CORRELATION WITH CLINICAL-PARAMETERS

被引:8
作者
LAI, MK
SUN, CF
CHEN, CS
HUANG, CC
CHU, SH
CHUANG, CK
机构
[1] CHANG GUNG MED COLL,CHANG GUNG MEM HOSP,DEPT PATHOL,TAIPEI 105,TAIWAN
[2] CHANG GUNG MED COLL,CHANG GUNG MEM HOSP,DEPT INTERNAL MED,TAIPEI 105,TAIWAN
关键词
D O I
10.1016/S0090-4295(94)80126-6
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives. To study deoxyribonucleic acid flow cytometry (DNA-FC) in pheochromocytomas and its correlation with clinical parameters. Methods. Fifty cases of pheochromocytomas of a total of 58 cases were studied for DNA-FC from archival paraffin-embedded tissue blocks and were correlated with clinical parameters (ie, size of tumor, benign or malignant pathologic type, vanillymandelic acid [VMA] level in 24 hour urine, age, sex, duration of symptoms, symptom scores). Results. A total of 19 cases were diploid while 31 cases (62%) showed DNA aneuploidy with 21 cases tetraploid. Four cases were malignant. All of them were tetraploid. However, among the 46 benign cases, 10 were aneuploid and 17 were tetraploid. All 19 cases with DNA diploidy were benign. The DNA-FC did not correlate with other clinical parameters in our study. Conclusions. We confirmed a high incidence of DNA aneuploidy in pheochromocytomas. All malignant pheochromocytomas were tetraploid and all cases with DNA diploidy were benign. Long-term follow-up of all cases, especially those with DNA aneuploidy (including tetraploidy), is mandatory.
引用
收藏
页码:185 / 188
页数:4
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