EXPRESSION OF ALPHA AND BETA-THYROID RECEPTORS DURING OLIGODENDROCYTE DIFFERENTIATION

被引：29

作者：

BAAS, D

BOURBEAU, D

CARRE, JL

SARLIEVE, LL

DUSSAULT, JH

PUYMIRAT, J

机构：

[1] CHU LAVAL, CTR RECH, UNITE MED GENET & MOLEC, Ste Foy G1V 4G2, PQ, CANADA

[2] CNRS, CTR NEUROCHIM, UPR 416, STRASBOURG, FRANCE

来源：

NEUROREPORT | 1994年 / 5卷 / 14期

关键词：

OLIGODENDROCYTE; THYROID RECEPTORS; THYROID HORMONE;

D O I：

10.1097/00001756-199409080-00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine which thyroid receptor (TR) isoforms are expressed during oligodendrocyte differentiation, we studied the expression of the mRNAs encoding two alpha (alpha 1 and alpha 2) and one (beta) TR isoforms in a bipotential oligodendrocyte-type 2-astrocyte (O-2A) progenitor cell line (CG-4) as well as in rat O-2A progenitor cells and oligodendrocytes. O-2A progenitor cells expressed only TR alpha-mRNAs, whereas oligodendrocytes and type 2-astrocytes also expressed TR beta 1-mRNAs. The differential expression of alpha 1 and beta 1 TRs suggests specific functions for both types of TRs during oligodendrocyte differentiation. We present evidence for a possible role of TR alpha 1 in the effect of thyroid hormones on the proliferation of CG-4 cells maintained as progenitor cells.

引用

页码：1805 / 1808

页数：4

共 22 条

[1] TRANSIENT EXPRESSION OF 3,5,3'-TRIIODOTHYRONINE NUCLEAR RECEPTORS IN RAT OLIGODENDROCYTES - IN-VIVO AND IN-VITRO IMMUNOCYTOCHEMICAL STUDIES [J].