DETERMINATION OF D,L-PROPARGYLGLYCINE AND N-ACETYLPROPARGYLGLYCINE IN URINE AND SEVERAL TISSUES OF D,L-PROPARGYLGLYCINE-TREATED RATS USING LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：5

作者：

JIANYING, Z

MACHIDA, Y

SUGAHARA, K

KODAMA, H

机构：

[1] KOCHI MED SCH,DEPT CHEM,KOCHI 783,JAPAN

[2] KOCHI MED SCH,DEPT PEDIAT,KOCHI 783,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 660卷 / 02期

关键词：

D O I：

10.1016/0378-4347(94)00296-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An experimental animal model with cystathioninuria was obtained by the injection of D,L-propargylglycine into rats. The concentrations of D,L-propargylglycine in urine, several tissues and serum at different times after the injection were measured by liquid chromatography-mass spectrometry. The propargylglycine accumulated rapidly in several tissues and serum of the rats, and reached its maximum level at about 2 h after the injection. Approximately 21.2% of the administered propargylglycine was excreted in urine. N-Acetylpropargylglycine was identified as a new metabolite of propargylglycine in urine. The concentration of propargylglycine was 100 times that of N-acetylpropargylglycine in urine.

引用

页码：375 / 379

页数：5

共 9 条

[1] ACETYLENIC ENZYME INACTIVATORS - INACTIVATION OF GAMMA-CYSTATHIONASE, IN-VITRO AND IN-VIVO, BY PROPARGYLGLYCINE [J].