EFFECTS OF AORTIC CONSTRICTION DURING EXPERIMENTAL ACUTE RIGHT-VENTRICULAR PRESSURE LOADING - FURTHER INSIGHTS INTO DIASTOLIC AND SYSTOLIC VENTRICULAR INTERACTION

被引:57
作者
BELENKIE, I
HORNE, SG
DANI, R
SMITH, ER
TYBERG, JV
机构
[1] UNIV CALGARY, FAC MED, DEPT MED, CALGARY, AB, CANADA
[2] UNIV CALGARY, FAC MED, DEPT MED PHYSIOL, CALGARY, AB T2N 4N1, CANADA
关键词
PULMONARY DISEASE; HYPERTENSION; ARTERIES;
D O I
10.1161/01.CIR.92.3.546
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Acute right ventricular (RV) hypertension may result in hemodynamic collapse. The associated reduction in left ventricular (LV) end-diastolic volume is thought to result from reduced RV output (secondary to RV ischemia) and adverse direct ventricular interaction. Aortic constriction improves cardiac function in these circumstances; this has been attributed to a reversal of the RV ischemia caused by an increased coronary perfusion pressure. We hypothesized that altered ventricular interaction, potentially via altered septal mechanics, may also contribute to the beneficial effects of aortic constriction. Methods and Results We instrumented nine dogs with ultrasonic dimension crystals to measure RV segment length, septum-to-RV free wall and septum-to-LV free wall diameters, and LV anteroposterior diameter. Catheter-tipped manometers were used to measure LV and RV pressures. Pericardial pressure was measured with hat, liquid-containing balloon transducers. Inflatable cuff constrictors were placed on the pulmonary artery (PA) and aorta, and a flow probe was placed on the PA. The right coronary artery (RCA) was perfused independently by a roller pump calibrated for flow. During moderate PA constriction, while RCA pressure was maintained at control level, RCA flow did not change significantly (15.8+/-6.2 to 16.9+/-11.5 mL/min) and was similar during severe PA constriction (18.6+/-9.8 mL/min). During severe PA constriction, RV stroke volume decreased from a control value of 10.3+/-4.9 to 2.3+/-1.4 mL/beat (P<.05). When aortic constriction was added while RCA pressure was maintained at control level, there was an increase in RV stroke volume to 4.5+/-2.0 mL/beat (P<.05) with no associated change in RCA flow (17.8+/-9.5 mL/min). However; pressure-dimension loops clearly demonstrated changes in diastolic and systolic ventricular interaction; with aortic constriction, there was a large increase in the transseptal pressure gradient associated with a rightward septal shift. During either isolated severe PA constriction or simultaneous severe PA and aortic constriction, RCA flow was increased until RCA pressure was approximately equal to that in the aorta. This produced an increase in RCA flow of 50% (P<.05); however, this increase in coronary flow was ineffective in improving any measure of RV function. Conclusions In this model of acute RV hypertension, aortic constriction improves cardiac function, at least in part, by altering ventricular interaction independent of changes in RCA flow. Changes in RCA flow do not appear to have a significant impact on cardiac function in this model in which coronary artery pressure was maintained at normal or increased levels.
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收藏
页码:546 / 554
页数:9
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