PROTON NMR OBSERVATION OF THE ANTINEOPLASTIC AGENT IPROPLATIN IN-VIVO BY SELECTIVE MULTIPLE-QUANTUM COHERENCE TRANSFER (SEL-MQC)

We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the lproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.