ENHANCED ANALGESIC ACTIVITY OF D-ALA2 ENKEPHALINAMIDES FOLLOWING D-ISOMER SUBSTITUTIONS AT POSITION 5

被引：18

作者：

BELLUZZI, JD

STEIN, L

DVONCH, W

DHEER, S

GLUCKMAN, MI

MCGREGOR, WH

机构：

来源：

LIFE SCIENCES | 1978年 / 23卷 / 02期

关键词：

D O I：

10.1016/0024-3205(78)90256-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：99 / 104

页数：6

共 15 条

[1] STRUCTURAL REQUIREMENTS FOR OPIOID ACTIVITY OF ANALOGS OF ENKEPHALINS [J].

BEDDELL, CR ;

CLARK, RB ;

HARDY, GW ;

LOWE, LA ;

UBATUBA, FB ;

VANE, JR ;

WILKINSON, S ;

CHANG, KJ ;

CUATRECASAS, P ;

MILLER, RJ .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 198 (1132) :249-265

[2] ANALGESIA INDUCED INVIVO BY CENTRAL ADMINISTRATION OF ENKEPHALIN IN RAT [J].

BELLUZZI, JD ;

GRANT, N ;

GARSKY, V ;

SARANTAKIS, D ;

WISE, CD ;

STEIN, L .

NATURE, 1976, 260 (5552) :625-626

[3] EVIDENCE FOR ANALGESIC ACTIVITY OF ENKEPHALIN IN MOUSE [J].

BUSCHER, HH ;

HILL, RC ;

ROMER, D ;

CARDINAUX, F ;

CLOSSE, A ;

HAUSER, D ;

PLESS, J .

NATURE, 1976, 261 (5559) :423-425

[4] OPIATE RECEPTOR AFFINITIES AND BEHAVIORAL-EFFECTS OF ENKEPHALIN - STRUCTURE-ACTIVITY RELATIONSHIP OF 10 SYNTHETIC PEPTIDE ANALOGS [J].

CHANG, JK ;

FONG, BTW ;

PERT, A ;

PERT, CB .

LIFE SCIENCES, 1976, 18 (12) :1473-1481

[5] SYNTHESIS AND OPIOID ACTIVITIES OF STEREOISOMERS AND OTHER D-AMINO-ACID ANALOGS OF METHIONINE-ENKEPHALIN [J].

COY, DH ;

KASTIN, AJ ;

SCHALLY, AV ;

MORIN, O ;

CARON, NG ;

LABRIE, F ;

WALKER, JM ;

FERTEL, R ;

BERNTSON, GG ;

SANDMAN, CA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 73 (03) :632-638

[6] PEPTIDES READILY PENETRATE BLOOD-BRAIN-BARRIER - UPTAKE OF PEPTIDES BY SYNAPTOSOMES IS PASSIVE [J].

GREENBERG, R ;

WHALLEY, CE ;

JOURDIKIAN, F ;

MENDELSON, IS ;

WALTER, R ;

NIKOLICS, K ;

COY, DH ;

SCHALLY, AV ;

KASTIN, AJ .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1976, 5 :151-158

[7] BREAKDOWN OF ENKEPHALIN AND ENDORPHIN ANALOGS BY BRAIN EXTRACTS [J].

GRYNBAUM, A ;

KASTIN, AJ ;

COY, DH ;

MARKS, N .

BRAIN RESEARCH BULLETIN, 1977, 2 (06) :479-484

[8] MODE OF DEACTIVATION OF ENKEPHALINS BY RAT AND HUMAN-PLASMA AND RAT-BRAIN HOMOGENATES [J].

HAMBROOK, JM ;

MORGAN, BA ;

RANCE, MJ ;

SMITH, CFC .

NATURE, 1976, 262 (5571) :782-783

[9] IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY [J].

HUGHES, J ;

SMITH, TW ;

KOSTERLITZ, HW ;

FOTHERGILL, LA ;

MORGAN, BA ;

MORRIS, HR .

NATURE, 1975, 258 (5536) :577-579

[10] BLOOD-BRAIN-BARRIER, HALF-TIME DISAPPEARANCE, AND BRAIN DISTRIBUTION FOR LABELED ENKEPHALIN AND A POTENT ANALOG [J].

KASTIN, AJ ;

NISSEN, C ;

SCHALLY, AV ;

COY, DH .

BRAIN RESEARCH BULLETIN, 1976, 1 (06) :583-589

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