CHANGES IN BRAIN-SEROTONIN AND 5-HYDROXYINDOLACETIC ACID LEVELS INDUCED BY 2,4-DICHLOROPHENOXYACETIC BUTYL ESTER

被引:22
作者
DEDUFFARD, AME [1 ]
DEALDERETE, MN [1 ]
DUFFARD, R [1 ]
机构
[1] NATL UNIV RIO CUARTO,FAC EXACT CHEM PHYS & NAT SCI,DEPT MOLEC BIOL,RA-5800 RIO CUARTO,ARGENTINA
关键词
5-Hydroxyindolacetic acid; 5-Hydroxytryptamine; Phenoxyherbicides; postnatal exposure; Pre-;
D O I
10.1016/0300-483X(90)90119-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Brain concentrations of Serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) were determined in male, mother and virgin female adult rats after exposure to 69 mg/kg body weight/day of 2,4-dichlorophenoxyacetic butyl ester (2,4-Dbe) during 15 or 45 consecutive days. Both 5-Ht and 5-HIAA concentrations were increased in the brain. These effects reverted to levels even lower than controls, when the animals were fed an untreated diet after the 2,4-Dbe treatment. High 5-HT and 5-HIAA brain concentrations were also observed in adult rats born from treated mothers (during pregnancy and lactancy) and fed with or without treated diet after weaning. Two different effects on serotoninergic system were detected: a transient effect if 2-Dbe was given to adult rats in a short period of time and a permanent effect if the herbicide supplied during pre- and post birth period (rat brain development). However, in utero exposed but lactationally cross-fostered rat pups were not affected, suggesting that prenatal exposure did not have any influence on the postnatal status of the neurotransmitter(s). © 1990.
引用
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页码:265 / 270
页数:6
相关论文
共 20 条
[1]  
BAGE G, 1973, ACTA PHARMACOL TOX, V32, P408
[2]   DISTRIBUTION OF 2,4,5-TRICHLOROPHENOXYACETIC ACID IN MOUSE FETUS [J].
COURTNEY, KD ;
EBRON, MT ;
TUCKER, AW .
TOXICOLOGY LETTERS, 1977, 1 (02) :103-108
[3]   RAPID METHOD FOR DETERMINATION OF 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID IN SMALL REGIONS OF RAT BRAIN [J].
CURZON, G ;
GREEN, AR .
BRITISH JOURNAL OF PHARMACOLOGY, 1970, 39 (03) :653-&
[5]   DEVELOPMENTAL VARIATIONS OF BRAIN-SEROTONIN, TRYPTOPHAN, 5-HYDROXYINDOLE ACETIC-ACID, AND NORADRENALINE AND DOPAMINE CONTENT IN 2 INBRED STRAINS OF MICE [J].
DASZUTA, A ;
BARRIT, MC ;
FAUDON, M .
DEVELOPMENTAL NEUROSCIENCE, 1982, 5 (2-3) :130-142
[6]  
DEDUFFARD AME, 1986, ANN M ARGENTINE SOC
[7]  
DUFFARD R, 1981, ACTA PHYSIOL LAT AM, V31, P35
[8]  
ELO H, 1970, TOXICOL APPL PHARM, V51, P439
[9]   PROBENECID-INDUCED ACCUMULATION OF 5-HYDROXYINDOLEACETIC ACID AND HOMOVANILLIC-ACID IN RAT-BRAIN [J].
EMANUELSSON, BM ;
PAALZOW, L ;
SUNZEL, M .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (09) :705-710
[10]   TEMPERATURE RESPONSES TO MONOAMINES AND AN INHIBITOR OF MAO INJECTED INTO CEREBRAL VENTRICLES OF RATS [J].
FELDBERG, W ;
LOTTI, VJ .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1967, 31 (01) :152-&