ANTIBODIES TO GP41 AND NEF IN OTHERWISE HIV-NEGATIVE HOMOSEXUAL MAN WITH KAPOSIS-SARCOMA

被引：16

作者：

BOWDEN, FJ

MCPHEE, DA

DEACON, NJ

CUMMING, SA

DOHERTY, RR

SONZA, S

LUCAS, CR

CROWE, SM

机构：

[1] MACFARLANE BURNET CTR MED RES,NATL CTR AIDS VIROL,FAIRFIELD,VIC 3078,AUSTRALIA

[2] FAIRFIELD HOSP,FAIRFIELD,VIC,AUSTRALIA

来源：

LANCET | 1991年 / 337卷 / 8753期

关键词：

D O I：

10.1016/0140-6736(91)92982-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A homosexual man with histologically confirmed Kaposi's sarcoma remained seronegative for HIV-1, HIV-2, and HTLV-I on conventional tests over a 4-year period. HIV cultures were also negative on thirteen separate occasions. However, serum antibodies to synthetic peptide analogues of the gp41 and nef regions of HIV-1 were consistently detected on an enzyme immunoassay. Tests with the polymerase chain reaction with primers directed to the gag and env regions were negative. The antigens to which the antibodies were produced might have come from a defective HIV mutant, another retrovirus, or a hitherto unknown "agent of Kaposi's sarcoma" with similar antigenic epitopes.

引用

页码：1313 / 1314

页数：2

共 11 条

[1] CHARACTERIZATION OF A DISTINCT SUBGROUP OF HIGH-RISK PERSONS WITH KAPOSIS-SARCOMA AND GOOD PROGNOSIS WHO PRESENT WITH NORMAL T4 CELL NUMBER AND T4-T8 RATIO AND NEGATIVE HTLV-III/LAV SEROLOGIC TEST-RESULTS [J].