RECEPTOR LIGANDS WHICH BIND THE OXYTOCIN RECEPTOR WITH SELECTIVITY AND HIGH-AFFINITY - CHEMICAL MODIFICATION OF A STREPTOMYCES-SILVENSIS DERIVED CYCLIC HEXAPEPTIDE

Oxytocin (OT) is a neurohypophyseal hormone which has been ascribed a pivotal role in parturition.1Evidence has accumulated to support the concept that the uterotonic action of OT and its stimulation of uterine prostaglandin release are events which combine to initiate labor.2’3Moreover, OT mediates the postpartum function of contracting the mammary myoepithelium to elicit milk let-down4 and has also recently been implicated as a key element in preterm labor5’6. © 1990, American Chemical Society. All rights reserved.