RECEPTOR LIGANDS WHICH BIND THE OXYTOCIN RECEPTOR WITH SELECTIVITY AND HIGH-AFFINITY - CHEMICAL MODIFICATION OF A STREPTOMYCES-SILVENSIS DERIVED CYCLIC HEXAPEPTIDE

被引:42
作者
BOCK, MG
DIPARDO, RM
WILLIAMS, PD
PETTIBONE, DJ
CLINESCHMIDT, BV
BALL, RG
VEBER, DF
FREIDINGER, RM
机构
[1] MERCK SHARP & DOHME LTD,DEPT BIOPHYS CHEM,W POINT,PA 19486
[2] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,RAHWAY,NJ 07065
关键词
D O I
10.1021/jm00171a003
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Oxytocin (OT) is a neurohypophyseal hormone which has been ascribed a pivotal role in parturition.1Evidence has accumulated to support the concept that the uterotonic action of OT and its stimulation of uterine prostaglandin release are events which combine to initiate labor.2’3Moreover, OT mediates the postpartum function of contracting the mammary myoepithelium to elicit milk let-down4 and has also recently been implicated as a key element in preterm labor5’6. © 1990, American Chemical Society. All rights reserved.
引用
收藏
页码:2321 / 2323
页数:3
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