REGULATION OF EXPRESSION OF BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE IN A RAT-TUMOR, ZAJDELA ASCITIC HEPATOMA

被引：5

作者：

JAIN, N ^{[1
]}

SUDHAKAR, C ^{[1
]}

DAS, MR ^{[1
]}

机构：

[1] CTR CELLULAR & MOLEC BIOL,HYDERABAD 500007,INDIA

来源：

FEBS LETTERS | 1993年 / 317卷 / 1-2期

关键词：

ALPHA-GALACTOSIDE ALPHA-2,6-SIALYTRANSFERASE; ZAJDELA ASCITIC HEPATOMA; REGULATION OF EXPRESSION; SIALIC ACID LEVEL;

D O I：

10.1016/0014-5793(93)81511-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor cell surface sialic acid levels determine a number of important properties governing cellular interactions and cell-cell communication. Towards understanding the mechanism of regulation of sialic acid levels upon cellular transformation, we have studied the regulation of expression of beta-galactoside alpha2,6-sialyltransferase in a rat tumor, the Zajdela ascitic hepatoma. We demonstrate distinct differences in the regulation of expression of the enzyme in the tumor cells as compared to normal liver cells. The expression of sialyltransferase is regulated both at the transcriptional and post-transcriptional level in a tissue-specific manner.

引用

页码：147 / 151

页数：5

共 33 条

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[2]

Beyer T A, 1981, Adv Enzymol Relat Areas Mol Biol, V52, P23

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