EFFICACY OF HISTAMINE-ANTAGONISTS AS ANTI-PRURITICS IN EXPERIMENTALLY INDUCED PRURITUS

被引：19

作者：

DAVIES, MG ^{[1
]}

MARKS, R ^{[1
]}

HORTON, RJ ^{[1
]}

STORARI, FE ^{[1
]}

机构：

[1] SK&F RES LTD,RES INST,WELWYN GARDEN CITY,HERTFORDSHIRE,ENGLAND

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1979年 / 266卷 / 02期

关键词：

Chlorpheniramine; Cimetidine; Histamineantagonists (H[!sub]1[!/sub] and H[!sub]2[!/sub]); Pruritus;

D O I：

10.1007/BF00694619

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

1. The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers. 2. A combination of cimetidine (H2 antagonist) and chlorpheniramine (H1 antagonist) proved effective in suppressing itch that was artificially induced by the application of papain and histamine. 3. The combination was more effective than chlorpheniramine or cimetidine alone or placebo. 4. The results suggest that both H1 and H2 receptors are involved in the mediation of pruritus. © 1979 Springer-Verlag.

引用

页码：117 / 120

页数：4

共 8 条

[1] DEFINITION AND ANTAGONISM OF HISTAMINE H2-RECEPTORS
BLACK, JW
PARSONS, EM
DURANT, CJ
DUNCAN, WAM
GANELLIN, CR
[J]. NATURE, 1972, 236 (5347) : 385 - &
[2] PHARMACOLOGICAL EVALUATION OF CIMETIDINE, A NEW HISTAMINE H2-RECEPTOR ANTAGONIST, IN HEALTHY MAN
BURLAND, WL
DUNCAN, WAM
HESSELBO, T
MILLS, JG
SHARPE, PC
HAGGIE, SJ
WYLLIE, JH
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1975, 2 (06) : 481 - 486
[3] ITCH - ROLE OF PROSTAGLANDINS
GREAVES, MW
MCDONALD.W
[J]. BRITISH MEDICAL JOURNAL, 1973, 3 (5881) : 608 - 609
[4] KEELE CA, 1964, SUBSTANCE PRODUCING, P125
[5] PRURITIC EFFECT OF BILE-SALTS
KIRBY, J
HEATON, KW
BURTON, JL
[J]. BMJ-BRITISH MEDICAL JOURNAL, 1974, 4 (5946): : 693 - 695
[6] PROSTAGLANDINS AND PRURITUS
LOVELL, CR
BURTON, PA
DUNCAN, EHL
BURTON, JL
[J]. BRITISH JOURNAL OF DERMATOLOGY, 1976, 94 (03) : 273 - 275
[7] RESPONSES OF HUMAN-SKIN BLOOD-VESSELS TO SYNTHETIC HISTAMINE ANALOGS
ROBERTSON, I
GREAVES, MW
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 5 (04) : 319 - 322
[8] THE NEUROHISTOLOGY AND NEUROPHYSIOLOGY OF THE ITCH SENSATION IN MAN
SHELLEY, WB
ARTHUR, RP
[J]. ARCHIVES OF DERMATOLOGY, 1957, 76 (03) : 296 - 323

← 1 →