ENZYME-CATALYZED HYDROLYSIS OF N-BENZYLOXYCARBONYL-CIS-2,6-(ACETOXYMETHYL)PIPERIDINE - A FACILE ROUTE TO OPTICALLY-ACTIVE PIPERIDINES

被引：17

作者：

CHENEVERT, R

DICKMAN, M

机构：

[1] Département de chimie, Faculté des Sciences, Génie Université Laval

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)86034-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report the first enzymatic asymmetrization of a piperidine system. Hydrolysis of N-benzyloxycarbonyl-cis-2,6-(acetoxymethyl)piperidine in the presence of Aspergillus niger lipase gave the corresponding 2R, 6S mono-acetate in good chemical yield and very high optical purity (ee greater-than-or-equal-to 98%).

引用

页码：1021 / 1024

页数：4

共 11 条

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