SEX-CHROMOSOME PAIRING AND ACTIVITY DURING MAMMALIAN MEIOSIS

被引：56

作者：

HANDEL, MA ^{[1
]}

HUNT, PA ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV, DEPT GENET, CLEVELAND, OH 44106 USA

来源：

BIOESSAYS | 1992年 / 14卷 / 12期

关键词：

D O I：

10.1002/bies.950141205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian sex chromosomes exhibit marked sexual dimorphism in behavior during gametogenesis. During oogenesis, the X chromosomes pair and participate in unrestricted recombination; both are transcriptionally active. However, during spermatogenesis the X and Y chromosomes experience spatial restriction of pairing and recombination, are transcriptionally inactive, and form a chromatin domain that is markedly different from that of the autosomes. Thus the male germ cell has to contend with the potential loss of X-encoded gene products, and it appears that coping strategies have evolved. Genetic control of sex-chromosome inactivation during spermatogenesis does not involve pairing or the presence of the Y chromosome or an intact X chromosome, and may therefore be under exogenous control by the gonad. Sex-chromosome reactivation during oogenesis and inactivation during spermatogenesis probably reflect specific meiotic events such as recombination. Understanding these phenomena may help explain other sex-related differences in genetic recombination.

引用

页码：817 / 822

页数：6

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