COMPARISON OF 4 HOMOLOGOUS RETENTION INDEX STANDARD SERIES FOR GAS-CHROMATOGRAPHY OF BASIC DRUGS

Four homologous retention index standard series with amine structure were evaluated for the screening of blood samples for basic drugs on NB-54 and DB-1701 capillary columns over a six-month period. An index series consisting of actual drug substances was used as a standard of comparison as it produced the most precise index values. The precision differences between the homologous series were generally small. On the intermediate-polarity column NB-1701, the 4-fluoroaniline series produced the most precise index values, whereas on the low-polarity column NB-54 the trialkylamine series was the most precise. These differences were thought to be caused by the polarity and basicity properties of the standards.