SYSTEMIC CYTOKINE ADMINISTRATION CAN AFFECT BLOOD-BRAIN-BARRIER PERMEABILITY IN THE RAT

被引：103

作者：

SAIJA, A ^{[1
]}

PRINCI, P ^{[1
]}

LANZA, M ^{[1
]}

SCALESE, M ^{[1
]}

ARAMNEJAD, E ^{[1
]}

DESARRO, A ^{[1
]}

机构：

[1] UNIV MESSINA, SCH MED, INST PHARMACOL, MESSINA, ITALY

来源：

LIFE SCIENCES | 1995年 / 56卷 / 10期

关键词：

BLOOD-BRAIN BARRIER; CYTOKINES; INTERLEUKIN-1-BETA;

D O I：

10.1016/0024-3205(95)00008-T

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of the present study was to clarify the effect of intracarotid injection of interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on the permeability of the blood-brain barrier (BBB) in the rat. A regional blood- to-brain transfer constant (Ki) for [C-14] alpha- aminoisobutyric acid ([C-14]AIB) and the cerebral residual blood volume were calculated 10 min following administration of cytokines (CKs; 1000 U/rat). The injection of IL-2 and IL-6 (but not of IL1 beta) induced a significant enhancement of Ki values for [C-14]AIB within several brain areas; conversely, when the rats were given TNF-alpha, a striking decrease in BBB permeability was observed. The cerebral regional blood volumes appeared significantly lower in the rats injected with IL-6 than in the control animals, but markedly increased following TNF-alpha administration. Our findings confirm the ability of some CKs to affect the permeability of the BBB and/or to act, probably indirectly, as vasomodulator agents of the cerebral microvessel endothelium.

引用

页码：775 / 784

页数：10

共 40 条

[1] LOCALIZATION OF INTERLEUKIN-2 IMMUNOREACTIVITY AND INTERLEUKIN-2 RECEPTORS IN THE RAT-BRAIN - INTERACTION WITH THE CHOLINERGIC SYSTEM [J].