INTRACEREBRAL SALINE - EFFECT ON MEMORY OF TRAINED MICE TREATED WITH PUROMYCIN

被引：37

作者：

FLEXNER, LB

FLEXNER, JB

机构：

[1] Department of Anatomy, Institute of Neurological Sciences, University of Pennsylvania, Philadelphia

来源：

SCIENCE | 1968年 / 159卷 / 3812期

关键词：

D O I：

10.1126/science.159.3812.330

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It was shown that puromycin administered to mice 1 or more days after maze-learning blocks expression of memory; the blockage can be removed by intracerebral injections of saline. We present evidence that intracerebral injections of saline are relatively ineffective in restoring memory when puromycin is administered either before or immediately after training; in these two situations puromycin appears to interfere with consolidation of memory.

引用

页码：330 / &

共 6 条

[1] MEMORY FIXATION IN GOLDFISH
AGRANOFF, BW
DAVIS, RE
BRINK, JJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (03) : 788 - &
[2] PUROMYCIN EFFECT ON SUCCESSIVE PHASES OF MEMORY STORAGE
BARONDES, SH
COHEN, HD
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[3] RESTORATION OF EXPRESSION OF MEMORY LOST AFTER TREATMENT WITH PUROMYCIN
FLEXNER, JB
FLEXNER, LB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 57 (06) : 1651 - &
[4] MEMORY IN MICE AS AFFECTED BY INTRACEREBRAL PUROMYCIN
FLEXNER, JB
FLEXNER, LB
STELLAR, E
[J]. SCIENCE, 1963, 141 (357) : 57 - &
[5] STAGES OF MEMORY IN MICE TREATED WITH ACETOXYCYCLOHEXIMIDE BEFORE OR IMMEDIATELY AFTER LEARNING
FLEXNER, LB
FLEXNER, JB
ROBERTS, RB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (02) : 730 - &
[6] MEMORY IN MICE ANALYZED WITH ANTIBIOTICS - ANTIBIOTICS ARE USEFUL TO STUDY STAGES OF MEMORY AND TO INDICATE MOLECULAR EVENTS WHICH SUSTAIN MEMORY
FLEXNER, LB
FLEXNER, JB
ROBERTS, RB
[J]. SCIENCE, 1967, 155 (3768) : 1377 - &

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