PRECURSOR KERATIN PROTEIN FROM HUMAN EPIDERMIS

被引：13

作者：

BAYNES, J ^{[1
]}

LEVINE, M ^{[1
]}

MCLEOD, A ^{[1
]}

WILKINSON, A ^{[1
]}

机构：

[1] UNIV MANCHESTER, DEPT BIOCHEM, MANCHESTER M13 9PL, LANCASHIRE, ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1978年 / 98卷 / 02期

关键词：

D O I：

10.1111/j.1365-2133.1978.tb01618.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Prekeratin has been isolated from human epidermis using the method of Matoltsy for bovine nose epidermis. Analysis by sedimentation equilibrium indicates that human prekeratin is heterogeneous in solution. The molecular weight range is from about 200 × 103 to at least 2 × 106. Polyacrylamide gel electrophoresis shows three polypeptide chains of molecular weights 65,000, 60,000 and 58,000. A lower than average ratio of polar/apolar amino acid residues suggests that hydrophobic interactions are important for stability. Copyright © 1978, Wiley Blackwell. All rights reserved

引用

页码：165 / 173

页数：9

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