INHIBITION OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE ACTIVITY POTENTIATES CYTOTOXICITY AND INDUCTION OF SCES IN HUMAN GLIOMA-CELLS RESISTANT TO 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA

被引：30

作者：

AIDA, T

CHEITLIN, RA

BODELL, WJ

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,BRAIN TUMOR RES CTR,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG,SAN FRANCISCO,CA 94143

来源：

CARCINOGENESIS | 1987年 / 8卷 / 09期

关键词：

D O I：

10.1093/carcin/8.9.1219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1219 / 1223

页数：5

共 29 条

[1]

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WILLIAMS, ME ;

DEEN, DF .

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[3] INCREASED REPAIR OF O6-ALKYLGUANINE DNA ADDUCTS IN GLIOMA-DERIVED HUMAN-CELLS RESISTANT TO THE CYTOTOXIC AND CYTOGENETIC EFFECTS OF 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA [J].

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[4]

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[6]

BOGDEN JM, 1981, NUCLEIC ACIDS RES, V9, P3089

[7] O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY CORRELATES WITH THE THERAPEUTIC RESPONSE OF HUMAN RHABDOMYOSARCOMA XENOGRAFTS TO 1-(2-CHLOROETHYL)-3-(TRANS-4-METHYLCYCLOHEXYL)-1-NITROSOUREA [J].

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[8] EXPOSURE OF HELA-CELLS TO O-6ALKYLGUANINES INCREASES SENSITIVITY TO THE CYTO-TOXIC EFFECTS OF ALKYLATING-AGENTS [J].

DOLAN, ME ;

CORSICO, CD ;

PEGG, AE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (01) :178-185

[9] DNA CROSS-LINKING AND MONOADDUCT REPAIR IN NITROSOUREA-TREATED HUMAN-TUMOR CELLS [J].

ERICKSON, LC ;

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[10] LACK OF INDUCTION OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE IN MAMMALIAN-CELLS TREATED WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE [J].

FOOTE, RS ;

MITRA, S .

CARCINOGENESIS, 1984, 5 (02) :277-281

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