EFFECT OF THYMIDINE ANALOGS ON TYROSINASE ACTIVITY AND MESSENGER-RNA ACCUMULATION IN MOUSE MELANOMA-CELLS

被引:10
作者
KIDSON, SH
DEHAAN, JB
机构
[1] Department of Anatomy and Cell Biology, University of Cape Town, Medical School
基金
英国医学研究理事会;
关键词
D O I
10.1016/0014-4827(90)90274-E
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The thymidine analog 5-bromodeoxyuridine (BrdU) has been found to inhibit terminal differentiation of a variety of cell types without significantly affecting the growth of these cells. We have compared the effect of BrdU with two other thymidine analogs, 5-iododeoxyuridine and 5-fluorodeoxyuridine, on the growth, tyrosinase activity, and tyrosinase-mRNA accumulation in BL-6 mouse melanoma cells. We show that all three analogs inhibit growth and tyrosinase activity, but only BrdU significantly inhibits the accumulation of tyrosinase mRNA. We consider these results in the light of current understanding of BrdU action. © 1990.
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页码:36 / 41
页数:6
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