PEANUT AGGLUTININ .4. TOOL FOR STUDYING HUMAN MONONUCLEAR CELL-DIFFERENTIATION

被引：42

作者：

LONDON, J

PERROT, JY

BERRIH, S

LAROCHE, L

NIAUDET, P

机构：

[1] Hopital Necker, Paris

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb03067.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peanut agglutinin (PNA) has previously been shown to be a ‘marker’ for early T subpopulations in mice. We have investigaied whether it could also be used in the study of human mononuclear cells. 50–60% of human thymocytes have binding sites for PNA. When separated on a discontinuous Ficoll gradient, the PNA‐positive thymocytes are found preferentially in the layers corresponding to the immunoincompetent cells. In the peripheral blood only 5% of the mononuclear cells are PNA‐positive and we have shown that these cells are monocytes. In tonsils 13% of PNA+ cells are found and they are mostly lymphocytes. Thus, PNA is a marker for some T cell subsets present in the thymus and tonsils. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：451 / 459

页数：9

共 30 条

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