CONTINUUM SOURCE ATOMIC FLUORESCENCE DETECTOR FOR LIQUID-CHROMATOGRAPHY

A preliminary study of interfacing of a high pressure liquid chromatography instrument with a continuous source atomic fluorescence detector is reported. The chemical system investigated is the acetylation reaction of ferrocene by acetic anhydride. The retention data from the conventional UV molecular absorption detector are in excellent agreement with those obtained using the atomic fluorescence detector monitoring the iron fluorescence signal. The metal-containing compounds are more easily quantitated with the fluorescence detector, both because it does not respond to purely organic interferants co-eluting with the compounds of interest and because the integrated response is insensitive to the chemical form of the compound. © 1979, American Chemical Society. All rights reserved.