MECHANISMS IN THE PATHOGENESIS OF POST-INFECTIOUS VACCINIA VIRUS ENCEPHALOMYELITIS IN THE MOUSE

被引：12

作者：

TSCHANNEN, R ^{[1
]}

STECK, AJ ^{[1
]}

SCHAFER, R ^{[1
]}

机构：

[1] UNIV BASEL,BIOZENTRUM,DEPT STRUCT BIOL,CH-4056 BASEL,SWITZERLAND

来源：

NEUROSCIENCE LETTERS | 1979年 / 15卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96129-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After intracranial replication of a neurotropic strain of vaccinia in mouse brain, analysis of the purified virus preparation reveals the presence of at least one host protein on the virus which was identified as the myelin basic protein. Vaccinia virus Elstree, a dermotropic virus may substitute for complete Freund's adjuvant (CFA) in inducing experimental allergic encephalomyelitis (EAE). Guinea pigs challenged with virus-myelin emulsions without CFA developed clinical and histological signs of EAE. © 1979.

引用

页码：295 / 300

页数：6

共 15 条

[1] INCREASED IMMUNOGENICITY OF PLASMA-MEMBRANES OF BHK-CELLS INFECTED BY VACCINIA VIRUS [J].

BANDLOW, G ;

KOSZINOWSKI, U ;

THOMSSEN, R .

ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG, 1973, 40 (1-2) :63-71

[2] RADIOIMMUNOASSAY FOR MYELIN BASIC-PROTEIN AND ITS USE FOR QUANTITATIVE MEASUREMENTS [J].

COHEN, SR ;

MCKHANN, GM ;

GUARNIERI, M .

JOURNAL OF NEUROCHEMISTRY, 1975, 25 (04) :371-&

[3] VACCINIA AS A MODEL FOR MEMBRANE BIOGENESIS [J].

DALES, S ;

MOSBACH, EH .

VIROLOGY, 1968, 35 (04) :564-&

[4] AMINO ACID SEQUENCE OF BASIC PROTEIN OF MYELIN MEMBRANE [J].

EYLAR, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 67 (03) :1425-&

[5]

HARTER DH, 1971, IMMUNOLOGICAL DISORD, P342

[6] BIOGENESIS OF POXIVRUSES - ROLE OF A-TYPE INCLUSIONS AND HOST CELL MEMBRANES IN VIRUS DISSEMINATION [J].

ICHIHASHI, Y ;

MATSUMOTO, S ;

DALES, S .

VIROLOGY, 1971, 46 (03) :507-+

[7] PURIFICATION OF FOUR STRAINS OF POXVIRUS [J].

JOKLIK, WK .

VIROLOGY, 1962, 18 (01) :9-&

[8]

KLEIMAN JH, 1975, J BIOL CHEM, V250, P2430

[9] COMPARISON OF POLYPEPTIDES OF 4 MEASLES-VIRUS STRAINS [J].

MOUNTCASTLE, WE ;

CHOPPIN, PW .

VIROLOGY, 1977, 78 (02) :463-474

[10]

Norton W.T., 1977, MYELIN, P161

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