INHIBITION OF GLUTAMATE RELEASE BY ARACHIDONIC-ACID IN RAT CEREBROCORTICAL SYNAPTOSOMES

被引:27
作者
HERRERO, I [1 ]
MIRASPORTUGAL, MT [1 ]
SANCHEZPRIETO, J [1 ]
机构
[1] UNIV COMPLUTENSE MADRID, FAC VET, DEPT BIOQUIM, E-28040 MADRID, SPAIN
关键词
ARACHIDONIC ACID; GLUTAMATE RELEASE; 4-AMINOPYRIDINE; TETRAETHYLAMMONIUM; CYTOSOLIC FREE CA-2+; PLASMA MEMBRANE POTENTIAL;
D O I
10.1111/j.1471-4159.1991.tb03805.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The action of arachidonic acid on glutamate release in rat cerebrocortical synaptosomes was investigated. The Ca2+-dependent release of glutamate evoked by 4-aminopyridine (4-AP) was inhibited by arachidonic acid (0.5-10-mu-M), but the KCl-evoked release was not modified. The Ca2+-independent release of glutamate was insensitive to low concentrations of arachidonic acid, but higher concentrations of this free fatty acid (30-mu-M) induced a slow efflux of cytoplasmic glutamate. The decrease in the Ca2+-dependent release of glutamate by arachidonic acid was consistent with a reduction in both the depolarization and the subsequent rise in the cytoplasmic free Ca2+ concentration induced by 4-AP in the nerve terminal. The inhibitory action by arachidonic acid observed in glutamate release was reversed in the presence of the K+-channel blocker tetraethylammonium.
引用
收藏
页码:718 / 721
页数:4
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