THE INTERACTION OF PHOSPHINE WITH HEMOGLOBIN AND ERYTHROCYTES

被引：24

作者：

CHIN, KL ^{[1
]}

MAI, X ^{[1
]}

MEAKLIM, J ^{[1
]}

SCOLLARY, GR ^{[1
]}

LEAVER, DD ^{[1
]}

机构：

[1] UNIV MELBOURNE,SCH SCI & MATH,PARKVILLE,VIC 3052,AUSTRALIA

来源：

XENOBIOTICA | 1992年 / 22卷 / 05期

关键词：

D O I：

10.3109/00498259209053123

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

1. Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent. 2. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate. 3. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process. 4. Uptake. of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.

引用

页码：599 / 607

页数：9

共 21 条

[1]

POTENTIOMETRIC DETERMINATION OF PHOSPHINE [J].

BERCK, B .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1968, 16 (03) :415-&

[2]

EXTRAMITOCHONDRIAL RELEASE OF HYDROGEN-PEROXIDE FROM INSECT AND MOUSE-LIVER MITOCHONDRIA USING THE RESPIRATORY INHIBITORS PHOSPHINE, MYXOTHIAZOL, AND ANTIMYCIN AND SPECTRAL-ANALYSIS OF INHIBITED CYTOCHROMES [J].

BOLTER, CJ ;

CHEFURKA, W .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 278 (01) :65-72

[3]

BOND E. J., 1967, Journal of Stored Products Research, V3, P289, DOI 10.1016/0022-474X(67)90032-X

[4]

Cherfuka W., 1976, PEST BIOCH PHYSL, V6, P65

[5]

ABSORPTION OF ZINC PHOSPHIDE PARTICLES [J].

CURRY, AS ;

PRICE, DE ;

TRYHORN, FG .

NATURE, 1959, 184 (4686) :642-643

[6]

THE METABOLISM OF AMINOPHENOLS IN ERYTHROCYTES [J].

ECKERT, KG .

XENOBIOTICA, 1988, 18 (11) :1319-1326

[7]

DETOXICATION OF N-OXYGENATED ARYLAMINES IN ERYTHROCYTES - AN OVERVIEW [J].

EYER, P .

XENOBIOTICA, 1988, 18 (11) :1327-1333

[8]

EYER P, 1975, MOL PHARMACOL, V11, P326

[9]

HUMAN GENOTOXICITY - PESTICIDE APPLICATORS AND PHOSPHINE [J].

GARRY, VF ;

GRIFFITH, J ;

DANZL, TJ ;

NELSON, RL ;

WHORTON, EB ;

KRUEGER, LA ;

CERVENKA, J .

SCIENCE, 1989, 246 (4927) :251-255

[10]

THE USE OF BIOLOGICAL MARKERS IN TOXICOLOGY [J].

HENDERSON, RF ;

BECHTOLD, WE ;

BOND, JA ;

SUN, JD .

CRITICAL REVIEWS IN TOXICOLOGY, 1989, 20 (02) :65-82

← 1 2 3 →