BENARTHIN - A NEW INHIBITOR OF PYROGLUTAMYL PEPTIDASE .2. PHYSICOCHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

被引：11

作者：

HATSU, M ^{[1
]}

NAGANAWA, H ^{[1
]}

AOYAGI, T ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] SHOWA COLL PHARMACEUT SCI,DEPT HYG CHEM,MACHIDA,TOKYO 194,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 07期

关键词：

D O I：

10.7164/antibiotics.45.1084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Benarthin, a new inhibitor of pyroglutamyl peptidase (PG-peptidase), has been isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. The structure of benarthin was determined to be L-(2,3-dihydroxybenzoyl)argininyl-L-threonine by analysis of spectral properties and through chemical studies.

引用

页码：1084 / 1087

页数：4

共 5 条

[1] BENARTHIN - A NEW INHIBITOR OF PYROGLUTAMYL PEPTIDASE .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES
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[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (07) : 1079 - 1083
[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
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[3] PREPARATION OF 2,3-DIHYDROXYBENZOIC ACID
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (01) : 621 - 622
[4] USE OF CHLORINE IN THE DETECTION OF COMPOUNDS ON PAPER CHROMATOGRAMS
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[5] BENARTHIN - A NEW INHIBITOR OF PYROGLUTAMYL PEPTIDASE .3. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS
HATSU, M
TUDA, M
MURAOKA, Y
AOYAGI, T
TAKEUCHI, T
[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (07) : 1088 - 1095

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