SUBSTITUTION OF LYSINE FOR ARGININE AT POSITION-42 OF HUMAN TRANSFORMING GROWTH FACTOR-ALPHA ELIMINATES BIOLOGICAL-ACTIVITY WITHOUT CHANGING INTERNAL DISULFIDE BONDS

被引：40

作者：

DEFEOJONES, D ^{[1
]}

TAI, JY ^{[1
]}

VUOCOLO, GA ^{[1
]}

WEGRZYN, RJ ^{[1
]}

SCHOFIELD, TL ^{[1
]}

RIEMEN, MW ^{[1
]}

OLIFF, A ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,DEPT CANC RES,W POINT,PA 19486

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1989年 / 9卷 / 09期

关键词：

D O I：

10.1128/MCB.9.9.4083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：4083 / 4086

页数：4

共 29 条

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[3] THE GENOME OF SHOPE FIBROMA VIRUS, A TUMORIGENIC POXVIRUS, CONTAINS A GROWTH-FACTOR GENE WITH SEQUENCE SIMILARITY TO THOSE ENCODING EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA
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[8] HUMAN TRANSFORMING GROWTH FACTOR-ALPHA - PRECURSOR STRUCTURE AND EXPRESSION IN ESCHERICHIA-COLI
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[9] GLOMQUIST MC, 1984, P NATL ACAD SCI USA, V81, P7363
[10] A MUTANT EPIDERMAL GROWTH-FACTOR RECEPTOR WITH DEFECTIVE PROTEIN TYROSINE KINASE IS UNABLE TO STIMULATE PROTOONCOGENE EXPRESSION AND DNA-SYNTHESIS
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