INDUCTION OF ERYTHROID DIFFERENTIATION IN FRIEND MURINE ERYTHROLEUKEMIC CELLS BY INORGANIC SELENIUM-COMPOUNDS

被引：19

作者：

EBERT, PS ^{[1
]}

MALININ, GI ^{[1
]}

机构：

[1] GEORGETOWN UNIV,DEPT PHYS,WASHINGTON,DC 20057

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)90871-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inorganic selenium compounds are shown to be inducers of hemoglobin synthesis in malignant murine erythroleukemia (MEL) cells. SeO2 can induce hemoglobin synthesis at 1 20 the concentration of butyric acid and 1 5000 the concentration of dimethylsulfoxide (DMSO), two potent inducers of erythroid differentiation in MEL cells. SeO2 and H2SeO3 showed an equivalent capacity to stimulate hemoglobin synthesis in three different MEL cell lines. The incorporation of 3H-glycine into hemoglobin was demonstrated in lysates of SeO2-induced MEL cells. © 1979.

引用

页码：340 / 349

页数：10

共 22 条

[1]

ABRAHAM E C, 1976, Hemoglobin, V1, P27, DOI 10.3109/03630267609031020

[2] INDUCTION BY OUABAIN OF HEMOGLOBIN SYNTHESIS IN CULTURED FRIEND ERYTHROLEUKEMIC CELLS [J].