INSULIN-DRIVEN ERYTHROPOIESIS MAY UNDERLIE IMPAIRMENT OF ERYTHROCYTE DEFORMABILITY IN HYPERINSULINEMIC, HYPERGLYCEMIC OB/OB-MICE

被引:7
作者
ENGSTROM, KG [1 ]
GRANKVIST, K [1 ]
TALJEDAL, IB [1 ]
机构
[1] UMEA UNIV HOSP,DEPT CLIN CHEM,S-90185 UMEA,SWEDEN
关键词
Erythrocyte; erythrocyte deformability; erythrocyte shape; erythropoiesis; insulin; ob/ob-mice;
D O I
10.1007/BF00404037
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The circulating erythrocytes in hyperglycaemic and hyperinsulinaemic obese (ob/ob) mice are enlarged with a decreased erythrocyte filtrability and an abnormally low resistance to osmotic stress. These changes probably reflect aberrations of erythropoiesis, as evidenced by enhanced staining for iron in the bone marrow, reticulocytosis, and increased erythrocyte volume fraction. Mature erythrocytes, reticulocytes, and late-phase basophilic erythroblasts were found to have larger diameters than their counterparts in control mice while myelopoiesis appeared to be unaffected. The average erythrocyte also displayed an increased cell volume and a decreased haemoglobin concentration. It is suggested that the stimulation of the erythroid cell line in ob/ob-mice might be a consequence of the hereditary hyperinsulinaemia. © 1990 Springer-Verlag.
引用
收藏
页码:127 / 130
页数:4
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