ESTIMATION OF THE CHLORAMPHENICOL AND CYCLOHEXIMIDE INHIBITION OF PROTEIN-SYNTHESIS IN BRAIN CHOLINERGIC SYNAPTOSOMES

被引:4
作者
CORBATON, V [1 ]
MUINO, MT [1 ]
FERNANDEZSILVA, P [1 ]
LOPEZPEREZ, MJ [1 ]
MONTOYA, J [1 ]
机构
[1] UNIV ZARAGOZA,FAC VET,DEPT BIOQUIM & BIOL MOLEC & CELULAR,MIGUEL SERVET 177,E-50013 ZARAGOZA,SPAIN
关键词
CHOLINERGIC; SYNAPTOSOME; MITOCHONDRIA; PROTEIN SYNTHESIS; CHLORAMPHENICOL; CYCLOHEXIMIDE;
D O I
10.1016/0006-8993(91)90049-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cholinergic synaptosomes have been prepared from sheep brain cortex by means of an immunoaffinity method using a specific anti-(Chol I) antiserum. The [C-14]leucine incorporation into proteins of this preparation shows a low cycloheximide and a high chloramphenicol sensitivity. This fact suggests that the mitochondrial protein synthesis system is the only one present in this fraction.
引用
收藏
页码:351 / 353
页数:3
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